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Table 1 Modular organization of Xyl-Doc enzymes and putative functions

From: The xyl-doc gene cluster of Ruminiclostridium cellulolyticum encodes GH43- and GH62-α-l-arabinofuranosidases with complementary modes of action

Locusa

Xyl-Doc enzymeb

Modular structurec

NCBI-protein ID

Putative functiond

Ccel_1229

GH4316-1229

S-GH4316-CBM6-DOC

ACL75585

Xylanase/α-l-arabinofuranosidase

Ccel_1230

GH10-1230

S-GH10-UNK-CBM6-DOC

ACL75586

Xylanase

Ccel_1231

GH4329-1231

S-GH4329-CBM6-DOC

ACL75587

Xylanase/xylosidase/α-l-arabinofuranosidase

Ccel_1232

CE1-1232

S-CE1-CBM6-DOC

ACL75588

Feruloyl esterase

Ccel_1233

GH4310-1233

S-GH4310-X19-CBM6-DOC

ACL75589

Xylosidase/α-l-arabinofuranosidase

Ccel_1234

GH62-1234

S-GH62-CBM6-DOC

ACL75590

α-l-Arabinofuranosidase

Ccel_1235

GH4329-1235

S-GH4329-CBM6-DOC

ACL75591

Xylanase/α-l-arabinofuranosidase

Ccel_1236

UNK-1236

S-COG3533-CBM22-UNK- DOC

ACL75592

Unknown

Ccel_1237

GH27-1237

S-GH27-UNK-CBM6-DOC

ACL75593

α-Galactosidase

Ccel_1238

GH59-1238

S-GH59-UNK-CBM6-DOC

ACL75594

α-Galactosidase

Ccel_1239

GH2-1239

S-UNK-GH2-UNK-CBM6-DOC

ACL75595

β-Galactosidase

Ccel_1240

GH62-CE6-1240

S-GH62-CBM6-DOC-CE6

ACL75596

α-l-Arabinofuranosidase/acetyl-xylan esterase

Ccel_1241

GH95-1241

S-UNK-GH95-CBM32-CBM6-DOC

ACL75597

Fucosidase

Ccel_1242

GH30-1242

S-GH30-UNK-CBM6-DOC

ACL75598

Glucuronoxylanase

  1. For GH, CE, and CBM, the family is given by an associated number according to the CAZy database [22]. For GH43 subfamily is mentioned by a subscript number [23]. UNK: module of unknown function. X19: additional module of unknown function found associated with GH43 catalytic module in some proteins. COG3533: uncharacterized conserved module. DOC: dockerin module
  2. S signal sequence, GH glycoside hydrolase, CE carbohydrate esterase, CBM carbohydrate-binding module
  3. axyl-doc gene cluster (loci Ccel_1229 to Ccel_1242)
  4. bNotation of each Xyl-Doc enzymes according to its DNA locus and GH family
  5. cModular organization
  6. dPutative function [19]