Fig. 5

Transcriptome remodeling during the transition to lipid accumulation. a Transcriptome profiles from L. starkeyi growing on either MMPCS or MMGX were k-means clustered and ordered based on average slope of the fold-change. Specific DNA motifs are enriched in the promoters of genes in clusters with the most positive and negative fold-change slopes. Enriched biological process gene ontology terms were identified from groups of genes with the specific DNA motifs in their promoters. The specific DNA motifs are associated with transcriptional regulators in S. cerevisiae. b Expression fold-change values from the transition point mapped to central metabolism pathways and lipid biosynthesis pathways are highly similar for L. starkeyi grown on MMPCS and MMGX