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Fig. 9 | Biotechnology for Biofuels

Fig. 9

From: Enhanced cellulase production by decreasing intercellular pH through H+-ATPase gene deletion in Trichoderma reesei RUT-C30

Fig. 9

Mechanistic model for decreasing intercellular pH by deleting the H+-ATPase gene tre76238, thus enhancing cellulase production in T. reesei. Deleting tre76238 impairs the ability of protons to be transported out of cells. Intracellular acid accumulation promotes a cytosolic Ca2+ burst that activates calcium signaling. The effects of adding LaCl3 suggest that Ca2+ channels are essential for cellulase production in Δ76238, using glucose as a repressive carbon source. Solid arrows indicate the data supported by our own experiments

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