Fig. 5From: Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycleSAM synthesis of the strain HSAM3 in flasks. a SAM titer of HSAM3 compared with different strains in initial fermentation medium. b SAM titer and cell growth of HSAM3 under batch and semi-continuous batch fermentation based on the optimized fermentation medium. Data are expressed as mean ± SD from triplicate measurements. Asterisks indicate a significant difference at p < 0.05Back to article page