Fig. 6
Dynamic modelling of organic acid fermentation comparing the wild-type with a solution from in silico evolution towards succinic acid production. Green solid lines correspond to an evolved succinic acid producer, using a solution that best represents the average and based on fitness (Table 6). Purple dashed lines correspond to the wild-type. Mutations were induced at the point of external phosphate depletion. a Change in biomass dry weight (g/L) over time. b Change in external phosphate concentration (g/L) over time. c Change in external organic acid concentration (g/L) over time. Lines are annotated to indicate the organic acid produced. d Change in external glucose concentration (g/L) over time