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Table 1 New reactions in iDU1756 and corresponding literature evidence

From: In silico evolution of Aspergillus niger organic acid production suggests strategies for switching acid output

KEGG reactioniDU1756 reactionFunctionEvidence
R06077CELLUe + H2Oe → BDGLCeCellulose degradation[44]
R06101STACe + H2Oe → MNNTe + FRUeStachyose degradation[45, 46]
R06202GALACTANe + H2Oe → GLACeGalactan degradation[47]
Not foundGALOL + NAD SOR + NADHOxidoreductive galactose catabolism[22, 23]
R00053D345THBe + H2Oe → 345THBeDigallate degradation[48,49,50,51,52]
R03372 + R03394IP6e + 4*H2Oe → IP2e + 4*PIePhytate degradation[53, 54]
R02997CLGe + H2Oe → CAFe + QTeChlorogenate degradation[55, 56]
R10040LNMe + H2Oe → ACHe + BDGLCeLinamarin degradation[57]
R02156QCTe + O2e → 2PCe + COeQuercetin degradation[58]
R02985AMYDe + H2Oe → PRNSe + DGLCeAmygdalin degradation[21]
R02558PRNSe + H2Oe → MDNe + DGLCeAmygdalin degradation[21]
R01767MDNe → HCNe + BALeAmygdalin degradation[21]
R04103PCNe + H2Oe  6APCNe + PHACePenicillin G degradation[59]
R030244NPPe + H2Oe → 4NPe + PIe4-nitrophenyl phosphate degradation[60,61,62,63,64]
R00505UDPGAL  UDPGALFUDP-alpha-d-galactofuranose for galactoglucomannan production[43]
R01758LAOL + NAD → LARAB + NADH + Hl-arabitol oxidation[65]
R09477XOL + NAD → XYL + NADH + HXylitol oxidation[65]
R02396ACCOAm + CARm  COAm + ALCARmMitochondrial acetyl transfer[24, 25]
Transport reactionCARm + ALCAR  CAR + ALCARmMitochondrial acetyl transfer[24, 25]
R02396ACCOA + CAR  COA + ALCARMitochondrial acetyl transfer[24, 25]
R00731TYR + O2 → LDOPA + H2Ol-Dopa production[66]
R00031O2 + 2*TYR → 2*LDOPAl-Dopa production[66]
R04300DPA + H2O + O2 → DHPHA + NH3 + H2O2Dopamine metabolism[67]
R02080LDOPA → DPA + CO2l-Dopa metabolism[66]
R00045O2 + 2*LDOPA → 2*DQ + 2*H2Ol-Dopa metabolism[66]
R01010T3P2 + H2O → GLYN + PIGlycolytic reaction[68]
R07253ACCOA + 3*MALCOA + NADPH → 6MSA + 4*COA + 3*CO2 + NADP + H2O6-methylsalicylate production[69]
R01408HCN + H2O → FMMCyanide degradation[70]
R02943TRP + DMPP → DMAT + PPITryptophan prenylation[71]
R01657DMPP + TRP → PPI + MBTTryptophan prenylation[71]
R05655PHN + O2 + NADH + H → PHNO + H2O + NADPhenanthrene degradation[72,73,74,75]
R00815PHL + O2 + NADPH + H → CCL + NADP + H2OPhenol degradation[76]
R01372PHPYR + O2 → 2HPAC + CO2Phenylalanine metabolism[77]
R01836TST + NAD → AND + NADH + HSteroid biotransformation[78]
R01838TST + NADP → AND + NADPH + HSteroid biotransformation[78]
R01837DHAND + NAD → AND + NADH + HSteroid biotransformation[78]
R07855PHAN + H2O → PHAC + NH3Phenylacetonitrile degradation[72, 79, 80]