Fig. 1

Overview of the strain lineages and data associated with each strain (a) and overview of the research approach and data analysis in this paper (b). A total of 16 strains were analyzed, covering three different lineages. For each stage of the analysis different data sets were collected. Four strains (LL1011, LL1043, LL374 and LL375) have been subjected to Adaptive Laboratory Evolution, as indicated in the figure. For description of the strain, the adaptation, data generation and analysis see “Methods” section