|
Bio-based products
|
Production pathway
|
Substrat
|
Nbr reaction step
|
NAD(P)H yield (mole/mole)
|
ATP yield (mole/mole)
|
Pathway yield (Yp)$
|
Yield efficiency (%)*
|
|---|
|
Ethylene glycol (EG)
|
NP-Dahms
|
Xylose
|
5
|
0
|
0
|
1
|
50
|
|
Xylulose-1-P
|
Xylose
|
4
|
− 1
|
− 1
|
0.87
|
50
|
|
Ribulose-1-P
|
Xylose
|
5
|
− 1
|
− 1
|
0.87
|
50
|
|
Serine pathway
|
Glucose
|
13
|
+2
|
0
|
2
|
83.3
|
|
X1P (R1P) + serine pathway
|
Xylose
|
7
|
+1
|
0
|
2
|
100
|
|
X1P (R1P) + serine pathway
|
Xylose + glucose
|
11
|
+2
|
0
|
4
|
91
|
|
Glycolic acid (GA)
|
CCM- (GS)$
|
Glucose
|
18
|
+6
|
+2
|
2
|
66
|
|
NP-Dahms
|
Xylose
|
5
|
+2
|
0
|
1
|
40
|
|
Xylulose-1-P
|
Xylose
|
4
|
+1
|
− 1
|
0.96
|
40
|
|
Ribulose-1-P
|
Xylose
|
5
|
+1
|
− 1
|
0.96
|
40
|
|
NP-Dahms + GS
|
Xylose
|
10
|
+2 (+1QH2)
|
0
|
2
|
80
|
|
X1P (R1P) + GS
|
Xylose
|
9
|
+ 3 + (1QH2
|
+1
|
2
|
80
|
|
X1P (R1P) + GS
|
Xylose + glucose
|
15
|
+2 + (3 QH2)
|
+3
|
4
|
73
|
|
1,4 Butanediol (BDO)
|
CCM$
|
Glucose
|
21
|
0
|
0
|
1
|
92
|
|
NP-Weimberg
|
Xylose
|
6
|
0
|
0
|
1
|
110
|
|
1,2,4 Butanetriol (BTO)
|
CCM$
|
Glucose
|
17
|
0
|
-1
|
1
|
83
|
|
NP-KDC
|
Xylose
|
5
|
0
|
0
|
1
|
100
|
|
3,4 dihydroxybutyric acid (3,4-DHBA)
|
CCM
|
Glucose
|
22
|
+3
|
0
|
1
|
66
|
|
NP-KDC
|
Xylose
|
5
|
+2
|
0
|
1
|
80
|
|
Mesaconic acid (MSA)
|
CCM$
|
Glucose
|
18
|
+3
|
+1
|
1
|
75
|
|
NP-Weimberg
|
Xylose
|
8
|
+1
|
0
|
1
|
91
|
|
Glutaric acid (GTA)
|
CCM$
|
Glucose
|
17
|
+ 5.66
|
+1.33
|
1
| |
|
NP-Weimberg + XI
|
Xylose
|
14
|
+4
|
0
|
0.66
|
62
|
- XI means xylose isomerase pathway
- $Yp is the stoichiometry pathway efficiency strictly calculated from the pathway without balancing ATP and cofactors
- *Yield efficiency is the ratio between the thermodynamic or energy yield and the pathway yield (Yp) as defined by [72]. The energy yield of these chemicals as produced from pentose or glucose can be found in Additional file 1: Table S4
- $ CCM-GS means Carbon central metabolism—glyoxylate shunt
