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Table 1 Xylose-based succinic acid production by various microorganisms

From: Bioproduction of succinic acid from xylose by engineered Yarrowia lipolytica without pH control

Organism Fermentation mode Feedstock (xylose fraction) Other sugars Xylose consumed (g/L) Succinic acid Main by-products (g/L) Reference
Titer (g/L) Yielda (g/g) Productivity (g/L/h)
A. succinogenes 130Z Batch SSL (72.6%) Galactose (12.2%), glucose (10.9%), mannose (4.2%), arabinose (0.1%) 30.2 27.4 0.70 0.45 FA (8.8) AA (12.6) [45]
B. succiniciproducens JF4016 Batch SSL (72.6%) Galactose (12.2%), glucose (10.9%), mannose (4.2%), arabinose (0.1%) 25.0 26.0 0.76 0.55 FA (3.3) AA (8.3) [45]
A. succinogenes 130Z Batch Pure xylose 22.00 14.2 0.64 0.67 [46]
A. succinogenes 130Z Batch SCB (-) 52.00 22.5 0.43 1.01 [46]
E. coli recombinant SD121 Batch Pretreated mother liquor (51.7%) Arabinose (10–15%), glucose (8–10%), galactose (8–10%) 37.01 52.1 0.63 0.62 AA (10) [47]
A. succinogenes CICC 11014 Batch Corncob hydrolysate (77.3%) Glucose (2.8%), arabinose (12.9%), cellobiose (7.0%) 38.1 23.64 0.58 0.49 [48]
E. coli BA204 Batch dual phase Pretreated cornstalk (80.7%) Glucose (13.5%) 8.1 11.13 1.03 0.70 AA (2.5) [49]
E. coli BA408 Batch Corn stalk hydrolysate (81.6%) Glucose (9.5%), arabinose (3.5%) 23 23.1 0.85 0.24 AA (< 0.5) [50]
B. succiniciproducens JF4016 Batch Pure xylose 7.67 4.6 0.60 0.80 FA (1.9), AA (2.6) [51]
A. succinogenes 130Z Batch Corn stover (73.4%) Glucose (10.1%), galactose (4.9%), arabinose (11.6%) 55.4 42.8 0.74 1.27 FA (-), AA
(-)
[33]
Y. lipolytica PSA02004PP Batch Pure xylose 60 11.2 0.19 0.13 AA (8.5) This study
Y. lipolytica PSA02004PP Batch SCB (90.5%) Glucose (6.0%), arabinose (3.6%) 37.8 5.6 0.13 0.09 AA (8.3) This study
Y. lipolytica PSA02004PP Fed-batch Pure xylose 150 22.3 0.15 0.14 AA (25) This study
  1. In all the studies mentioned above except current work, pH was controlled/maintained either by automatic addition of alkali agents or supplementing culture medium with pH regulators
  2. Italic values represent the result obtained in this study
  3. AA acetic acid, FA formic acid, SSL-spent sulphite liquor
  4. aThe yield is calculated on the basis of total sugars consumed