Fig. 4
Estimates of Michaelis constants, Km’s, predicted by ORACLE. Distribution of Km’s estimated with ORACLE (red boxplots) without imposing experimental values from BRENDA (black circles denote experimental values of Km’s with consistent ORACLE estimates, whereas orange circles denote the ones with inconsistent ORACLE estimates). Whiskers represent minimal and maximal value predicted by ORACLE. Notation, e.g., PPC@pep denotes the Michaelis constant, i.e., the concentration of Phosphoenolpyruvate (pep) at which the reaction rate of Phosphoenolpyruvate carboxylase (PPC) is half of Vmax. Full names of reactions are provided in Additional file 1: Table S3