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Table 2 Ranges of the original set of parameters computed by ORACLE and of the refined set of parameters inferred by the iSCHRUNK method

From: Large-scale kinetic metabolic models of Pseudomonas putida KT2440 for consistent design of metabolic engineering strategies

ParameterOriginal ranges (mM)Refined ranges (mM)
\(K_{{{\text{m}},2{\text{dhglcn}}}}^{{2{\text{DHGLCNtex}}}}\)6.83 ·× 10−5–0.686.83 ·× 10−5–2.34 · 10−3
\(K_{{{\text{m}},2{\text{dhglcn}}}}^{{{\text{GAD}}2{\text{ktpp}}}}\)6.83 ·× 10−5–0.686.83 ·× 10−5–0.133
\(K_{{{\text{m}},{\text{q}}8}}^{\text{GLCDpp}}\)3.81 ·× 10−3–37.713.81 ·× 10−3–0.899
\(K_{{{\text{m}},{\text{glcn}}}}^{\text{GLCDpp}}\)0.01–107.370.01–5.76
\(K_{{{\text{m}},{\text{glcn}}}}^{{{\text{GLCNt}}2{\text{rpp}}}}\)2.63 ·× 10−5–0.266.54 ·× 10−4–9.49 · 10−4
\(K_{{{\text{m}},{\text{adp}}}}^{\text{GNK}}\)2.03 ·× 10−3–203.84 ·× 10−2–20
\(K_{{{\text{m}},6{\text{pgc}}}}^{\text{GNK}}\)4.26 ·× 10−5–0.424.26 ·× 10−5–8.37 · 10−2
  1. 2DHGLCNtex, ketogluconate transport via diffusion extracellular to periplasm; GAD2ktpp, gluconate 2 dehydrogenase periplasm; GLCDpp, glucose dehydrogenase ubiquinone 8 as acceptor periplasm; GLCNt2rpp, d-gluconate transport via proton symport reversible periplasm; GNK, gluconokinase; 2dhglcn, 2-dehydro-d-gluconate; 6pgc, 6-phospho-d-gluconate; adp, ADP; glcn, d-gluconate; q8, ubiquinone-8