Table 5 A comparison of intracellular metabolites in CRZ14e and CRZ14e-ED
Metabolite | Intracellular metabolite (mM) | Ratio | P valuea | |
|---|---|---|---|---|
CRZ14e | CRZ14e-ED | |||
G6P | 0.22 ± 0.01 | 0.25 ± 0.02 | 1.1 | 0.04 |
F6P | 0.03 ± 0.00 | 0.03 ± 0.01 | 1.0 | 0.27 |
FBP | 34 ± 3 | 38 ± 2 | 1.1 | 0.12 |
DHAP | 3.4 ± 0.1 | 3.7 ± 0.2 | 1.1 | 0.03 |
GAP | 0.16 ± 0.01 | 0.23 ± 0.03 | 1.4 | 0.02 |
BPG | 0.04 ± 0.02 | 0.08 ± 0.01 | 2.0 | 0.02 |
3PG | 0.72 ± 0.08 | 1.15 ± 0.06 | 1.6 | 0.00 |
PEP | 0.12 ± 0.00 | 0.17 ± 0.02 | 1.4 | 0.02 |
PYR | 2.18 ± 0.41 | 2.29 ± 0.13 | 1.1 | 0.68 |
Ru5P | 0.19 ± 0.01 | 0.12 ± 0.01 | 0.6 | 0.00 |
R5P | 0.09 ± 0.01 | 0.07 ± 0.00 | 0.8 | 0.02 |
6PG | 0.03 ± 0.00 | 0.09 ± 0.01 | 3.0 | 0.00 |
ADP | 0.37 ± 0.02 | 0.32 ± 0.03 | 0.9 | 0.07 |
ATP | 1.70 ± 0.05 | 1.92 ± 0.10 | 1.1 | 0.02 |
NAD | 0.28 ± 0.03 | 0.37 ± 0.07 | 1.3 | 0.14 |
NADH | 0.07 ± 0.00 | 0.07 ± 0.02 | 1.0 | 0.97 |
NADP | 0.17 ± 0.02 | 0.11 ± 0.01 | 0.6 | 0.01 |
NADPH | 0.02 ± 0.01 | 0.10 ± 0.01 | 5.0 | 0.00 |
KDPG | 0.00 ± 0.00 | 0.09 ± 0.01 | NA | 0.00 |
ATP/ADP | 4.64 ± 0.29 | 5.98 ± 0.49 | 1.3 | 0.02 |
NADH/NAD | 0.24 ± 0.02 | 0.19 ± 0.09 | 0.8 | 0.45 |