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Table 2 DHA yield in Schizochytrium sp. from the literatures and this study

From: Overproduction of docosahexaenoic acid in Schizochytrium sp. through genetic engineering of oxidative stress defense pathways

Schizochytrium sp.

Strategy

Cultivation mode

Yield (g/L)

Content (%TFA)

Reference

S056

HX-308

Optimization of sea salt

ALE

Shake flask

1,500-L fermentor

8.0

38.1

44.4

53.3

[30]

[31]

HX-308

Addition of ascorbic acid

5-L bioreactor

38.3

54.5

[3]

SR21

Addition of inositol

Shake flask

8.5

37.3

[33]

HX-308

MYA1381

ATCC20888

ATCC20888

ATCC20888

Continuous feeding

Metabolic engineering

Metabolic engineering

Metabolic engineering

Metabolic engineering

Fed-batch

Shake-flask/ Fed-batch

Shake-flask

Shake-flask

Shake-flask/ Fed-batch

38.4

7.0/ 47.4

3.5

6.4

8.8/ 13.3

55.0

42.9

N.C

37.9

42.8

[32]

[11]

[12]

[10]

This study

  1. ALE: Adaptive laboratory evolution, N.C.: not calculated