Name | Chemical reporter | Probe | Bioorthogonal | Ref |
---|
CuAAC | Terminal alkyne | Azide | Copper toxicity | [162,163,164] |
Azide | Terminal alkyne | Copper chelating agent | [165] |
SPAAC | Azide | Strained cycloalkyne | Yes | [166,167,168] |
\(\hbox {DA}_{{inv}}\) | Strained/cyclic | Tetrazine | Yes | [168,169,170] |
Alkenes/alkynes | | | |
- CuAAC Cu(I)-catalyzed azide–alkyne cycloaddition, SPAAC strain-promoted alkyne-azide cycloaddition, \({DA}_{{inv}}\) inverse electron demand Diels-Alder