TY - JOUR AU - Pang, Ai-Ping AU - Wang, Haiyan AU - Zhang, Funing AU - Hu, Xin AU - Wu, Fu-Gen AU - Zhou, Zhihua AU - Wang, Wei AU - Lu, Zuhong AU - Lin, Fengming PY - 2021 DA - 2021/03/26 TI - High-dose rapamycin exerts a temporary impact on T. reesei RUT-C30 through gene trFKBP12 JO - Biotechnology for Biofuels SP - 77 VL - 14 IS - 1 AB - Knowledge with respect to regulatory systems for cellulase production is prerequisite for exploitation of such regulatory networks to increase cellulase production, improve fermentation efficiency and reduce the relevant production cost. The target of rapamycin (TOR) signaling pathway is considered as a central signaling hub coordinating eukaryotic cell growth and metabolism with environmental inputs. However, how and to what extent the TOR signaling pathway and rapamycin are involved in cellulase production remain elusive. SN - 1754-6834 UR - https://doi.org/10.1186/s13068-021-01926-w DO - 10.1186/s13068-021-01926-w ID - Pang2021 ER -