Target modification | Theoretical lipid yield | The source of NADH (mmol) | The source of NADPH (mmol) | Demand of ATP (mmol) | Acetyl-CoA production (mmol) | The carbon loss distribution (C-mol/C-mol, %) | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(C-mol/C-mol) | (g/g) | Glycolysis | TCA | Others | PPP | NADH | Others | PPP | Glycolysis/ Gluconeogenesis | TCA | |||
Glucose | |||||||||||||
Original model | 0.524 | 0.273 | 29.71 | 0 | 0 | 27.43 | ✗ | 0 | 63.62 | 14.86 | 22.86 | 24.76 | 0 |
NADP-dependent GAPDH | 0.598 | 0.311 | 16.96 | 0 | 0 | 14.35 | ✗ | 16.96d | 71.86 | 16.96 | 11.96 | 28.26 | 0 |
NADP-dependent ALD | 0.598 | 0.311 | 16.96 | 0 | 0 | 14.35 | ✗ | 16.96e | 71.86 | 16.96 | 11.96 | 28.26 | 0 |
NADP-dependent ME | 0.602 | 0.313 | 34.15 | 0 | 0 | 13.62 | 17.89a | 0 | 73.13 | 17.07 | 11.36 | 28.45 | 0 |
Transhydrogenases | 0.643 | 0.335 | 38.60 | 2.11 | 0 | 0 | 32.62b | 1.06f | 59.71 | 18.24 | 0 | 32.16 | 3.52 |
Reversible ICDHxm | 0.643 | 0.335 | 38.60 | 2.11 | 0 | 0 | 32.62c | 1.06f | 59.71 | 18.24 | 0 | 32.16 | 3.52 |
Cellobiose | |||||||||||||
Original model | 0.524 | 0.287 | 59.43 | 0 | 0 | 54.86 | ✗ | 0 | 121.90 | 29.71 | 22.86 | 24.76 | 0 |
NADP-dependent GAPDH | 0.598 | 0.327 | 33.92 | 0 | 0 | 28.70 | ✗ | 33.91d | 138.38 | 33.91 | 11.96 | 28.26 | 0 |
NADP-dependent ALD | 0.598 | 0.327 | 33.92 | 0 | 0 | 28.70 | ✗ | 33.91e | 138.38 | 33.91 | 11.96 | 28.26 | 0 |
NADP-dependent ME | 0.606 | 0.332 | 68.73 | 0 | 0 | 25.88 | 37.56a | 0 | 143.35 | 34.36 | 10.78 | 28.64 | 0 |
Transhydrogenases | 0.649 | 0.355 | 77.17 | 3.59 | 0 | 0 | 66.13b | 1.79f | 114.67 | 36.79 | 0 | 32.15 | 2.99 |
Reversible ICDHxm | 0.649 | 0.355 | 77.17 | 3.59 | 0 | 0 | 66.13c | 1.79f | 114.67 | 36.79 | 0 | 32.15 | 2.99 |
Xylose | |||||||||||||
Original model | 0.471 | 0.245 | 22.29 | 0 | 10 g | 30.57 | ✗ | 0 | 49.05 | 11.14 | 30.57 | 22.29 | 0 |
NADP-dependent GAPDH | 0.538 | 0.280 | 12.72 | 0 | 10 g | 20.76 | ✗ | 12.72d | 55.22 | 12.72 | 20.76 | 25.43 | 0 |
NADP-dependent ALD | 0.538 | 0.280 | 12.72 | 0 | 10 g | 20.76 | ✗ | 12.72e | 55.22 | 12.72 | 20.76 | 25.43 | 0 |
NADP-dependent ME | 0.583 | 0.303 | 27.56 | 0 | 10Â g | 14.15 | 21.29a | 0 | 66.90 | 13.78 | 14.15 | 27.56 | 0 |
Transhydrogenases | 0.641 | 0.334 | 32.17 | 1.87 | 10Â g | 0 | 37.03b | 0.93f | 50.55 | 15.15 | 0 | 32.17 | 3.74 |
Reversible ICDHxm | 0.641 | 0.334 | 32.17 | 1.87 | 10Â g | 0 | 37.03c | 0.93f | 50.55 | 15.15 | 0 | 32.17 | 3.74 |
Glycerol | |||||||||||||
Original model | 0.524 | 0.267 | 14.86 | 0 | 0 | 13.71 | ✗ | 0 | 36.76 | 7.43 | 22.86 | 24.76 | 0 |
NADP-dependent GAPDH | 0.598 | 0.304 | 8.48 | 0 | 0 | 7.17 | ✗ | 8.48d | 39.79 | 8.48 | 11.96 | 28.26 | 0 |
NADP-dependent ALD | 0.598 | 0.304 | 8.48 | 0 | 0 | 7.17 | ✗ | 8.48e | 39.79 | 8.48 | 11.96 | 28.26 | 0 |
NADP-dependent ME | 0.637 | 0.324 | 18.07 | 0 | 0 | 3.72 | 12.96a | 0 | 45.31 | 9.03 | 6.20 | 30.11 | 0 |
Transhydrogenases | 0.679 | 0.346 | 19.26 | 0 | 0 | 0 | 17.78b | 0 | 37.41 | 9.63 | 0 | 32.10 | 0 |
Reversible ICDHxm | 0.679 | 0.346 | 19.26 | 0 | 0 | 0 | 17.78c | 0 | 37.41 | 9.63 | 0 | 32.10 | 0 |
Acetic acid | |||||||||||||
Original model | 0.470 | 0.245 | 0 | 9.27 | 0 | 4.49 | ✗ | 3.71f | 31.11 | 4.45 | 11.24 | 4.60 | 37.14 |
NADP-dependent GAPDH | 0.465 | 0.242 | 0 | 8.85 | 0 | 6.05 | ✗ | 3.25f | 32.18 | 4.40 | 15.13 | 5.89 | 32.46 |
NADP-dependent ALD | 0.470 | 0.245 | 0 | 9.27 | 0 | 4.49 | ✗ | 3.71f | 31.11 | 4.45 | 11.24 | 4.60 | 37.14 |
NADP-dependent ME | 0.470 | 0.245 | 0 | 9.27 | 0 | 4.49 | 0 | 3.71f | 31.11 | 4.45 | 11.24 | 4.60 | 37.14 |
Transhydrogenases | 0.485 | 0.252 | 0 | 10.48 | 0 | 0 | 3.40b | 5.06f | 29.74 | 4.58 | 0 | 0.88 | 50.63 |
Reversible ICDHxm | 0.485 | 0.252 | 0 | 10.48 | 0 | 0 | 3.40c | 5.06f | 29.74 | 4.58 | 0 | 0.88 | 50.63 |