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Table 2 Performance of the best transformant per gene combination after 1st stage of strain development

From: Rational engineering of Saccharomyces cerevisiae towards improved tolerance to multiple inhibitors in lignocellulose fermentations

Gene combination Strain Resistance phenotype EtOH yield % increment Growth (OD600) % increment
ARI + ADH6 AA6 Furans + weak acids 15.80 19.50
ARI1 + FDH1 AF10 Furans + weak acids − 5.55 7.92
ARI1 + ICT1 AI1 Furans + weak acids + organic solvents 1.25 − 12.00
PAD1 + ADH6 PA7 Phenolics + furans + weak acids − 1.97 3.40
PAD1 + FDH1 PF5 Phenolics + weak acids − 15.40 31.80
PAD1 + ICT1 PI3 Phenolics + weak acids + organic solvents − 3.58 20.90
TAL1 + ADH6 TA6 Furans + weak acids 3.60 18.60
TAL1 + FDH1 TF2 Weak acids 16.90 6.20
TAL1 + ICT1 TI10 Weak acids + organic solvents − 8.34 − 22.30