Fig. 2

Metabolomics analysis of engineered S. elongatus under high salinity condition. A Schematic diagram of cyanobacterial central metabolic pathways. Red and green represent up and downregulated metabolites identified from untargeted metabolomics, respectively. Blue represent downregulated metabolites identified from Fig. 3. Ru5P ribulose-5-phosphate, RuBP ribulose-1,5-bisphosphate, 3-PG 3-phosphoglycerate, BPG 1,3-diphosphoglycarate, GAP glyceraldehyde-3-phosphate, DHAP dihydroxyacetone phosphate, F6P fructose-6-phosphate, FBP fructose-1,6-bisphosphate, E4P erthrose-4-phosphate, SBP sedoheptulose-1,7-bisphosphate, S7P sedoheptulose-7-phosphate, R5P ribose-5-phosphate, PEP phosphoenolpyruvate, PYR pyruvate, Ace-COA acetyl-CoA, OAA oxaloacetate, CTA citrate, ICT isocitrate, α-KET α-ketoglutarate, SUL-CoA succinyl-CoA, SUC succinate, FUM fumarate, MAL malate, Ala alanine, Asp aspartate, Glu glutamate, Gln glutamine, Met methionine, Tyr tyrosine, Phe phenylalanine, Ile isoleucine. B Heatmap and statistical analysis of 42 differential accumulated metabolites localized in cyanobacterial central metabolic pathway