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Fig. 3 | Biotechnology for Biofuels

Fig. 3

From: RNA sequencing reveals metabolic and regulatory changes leading to more robust fermentation performance during short-term adaptation of Saccharomyces cerevisiae to lignocellulosic inhibitors

Fig. 3

Unsupervised clustering of the RNA sequencing data showing differential expression in short-term adaptation of S. cerevisiae CR01 to lignocellulosic hydrolysate during aerobic propagation. Samples were taken at four times during the feeding phase of propagation (t1 = 13.5 h, t2 = 21.5 h, t3 = 29.5 h and t4 = 41.5 h). Results from all sampled biological replicates are shown (n = 3 or 4). A Multidimensional scaling of the RNA sequencing data shows major variation between t4 from adapting versus non-adapting cultures, with low variability between replicates. B Heatmap of the 50 most variable genes across all samples showing the differential expression during the feeding phase, including up- and down-regulation of certain biosynthetic pathway genes. C Heatmap of the 50 most differentially expressed genes between non-adapting and adapting cultures at the t4 time-point

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Biotechnology for Biofuels and Bioproducts

ISSN: 2731-3654

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