Fig. 8From: RNA sequencing reveals metabolic and regulatory changes leading to more robust fermentation performance during short-term adaptation of Saccharomyces cerevisiae to lignocellulosic inhibitorsTranscriptional response of the biotin and thiamine biosynthetic pathways in hydrolysate-adapting vs. non-adapting propagation cultures, showing up-regulation of both pathways over time (time points t1–t4). A Clustered thiamine biosynthetic genes were up-regulated during propagation (red shades denote up-regulation, and blue shades down-regulation). The results for all biological replicates are shown (n = 3 or 4). B Thiamine biosynthetic pathway genes were significantly (p-value < 10–4) up-regulated at the end of adapting vs. non-adapting cultivations (indicated by colored reaction arrows and text). C Biotin biosynthetic pathway genes were significantly up-regulated (p-value < 10–4) at the end of adapting vs. non-adapting cultivations (indicated by colored reaction arrows and text)Back to article page