Fig. 1

Phenotypic variance across 1125 F₆ hybrids derived from a cross between S. cerevisiae strains RM11-1a and YJM975α [34]. Each of the 987 hybrids that did not display a growth defect on maltose was tested in conditions mimicking industrial beer fermentation (16^oP at 20 °C for 7 days), after which concentration of primary (ethanol) and secondary metabolites (glycerol, acetic acid, higher alcohols and esters) were determined for each sample. In addition, the growth of all 1125 F₆ segregants was measured in the presence of high osmolarity (sorbitol), salt, acetic acid, ethanol, acetic acid and sulfite (SO3²⁻). Spearman rank correlations were calculated for each pair of phenotypes, rho values are indicated here with corresponding significance (p < 0.10, *p < 0.05, **p < 0.01, ***p < 0.001)