Fig. 5
From: Synthetic biology toolkit for engineering Cupriviadus necator H16 as a platform for CO2 valorization
Schematic of the biosynthetic pathways for producing terpenoids in C. necator H16. Mevalonate (MVA, shown in blue) pathway and 2-C-methyl-D-erythritol-4-phosphate (MEP, shown in orange) pathway are two major pathways for terpenoid biosynthesis. Native genes are shown in blue, while heterologous genes are shown in red. HMG-CoA: 3-hydroxy-3-methyl glutaryl coenzyme A; MVA: mevalonic acid; PMVA: mevalonate-5-phosphate; DPMVA: mevalonate-5-pyrophosphate; DXP: 1-deoxy-D-xylulose-5-phosphate; MEP: 2-C-methyl-d-erythritol-4-phosphate; CDP-ME: 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythrito; CDP-MEP: 4-(cytidine 5′-diphospho)-2-C-Methyl-d-erythritol-4-phosphate; MECPP: 2-C-methyl-d-erythritol-2,4-cyclodiphosphate; HMBPP: 1-hydroxy-2-meyhyl-2-butenyl-4-diphosphate; IPP: isopentenyl-5-pyrophosphate; DMAPP: dimethylallyl-pyrophosphate; GPP: geranyl-pyrophosphate; FPP: farnesyl-pyrophosphate