Table 5 Products synthesized in C. necator from CO₂

Acetoin

Plasmid (Tc^R, RSF1010, par)

P_phb-alsSD

H16ΔacoABCΔphaC1ΔphaC2

Gas fermentation

0.32 mol acetoin/mol CO₂

[188]

2,3-Butanediol

Integration (phaC1AB1)

P_araBAD-alsSD-sadh

H16ΔacoXABC ΔphaC1AB1

Gas fermentation

32.0 ± 0.1 g/L

[139]

Isopropanol

Integration (phaC1)

P_araBAD-ctfAB-adc-sadh-phaA

H16ΔphaC1B1

Gas fermentation

7.7 ± 0.2 g/L

[139]

Plasmid pEG7b (Kan^R, pBBR1)

P_tac-thl-ctf-adc-adh

H16ΔphaCABΔphaB2 ΔphaB3

Gas fermentation

3.5 g/L

[138]

Plasmid pEG12 (Kan^R, pBBR1)

P_lac-thl-thl-ctf-adc-adh

H16ΔphaCABΔphaB2 ΔphaB3

MES

216 mg/L

[25]

Plasmid pEG12 (Kan^R, pBBR1)

P_lac-thl-thl-ctf-adc-adh

H16ΔphaCABΔphaB2 ΔphaB3

MES

 ~ 600 mg/L

[10]

n-Butanol

Plasmid pLH205 (Kan^R, pBHR1)

P_CAT-phaJ-phaAB-terOP-bldh-yqhD

H16

Formic acid

30 mg/L

[151]

Isobutanol and 3-methyl-1-butanol

Plasmid JL26 (Kan^R, pBBR1)

P_lac-ilvBHCD-kivd

DJ21ΔphaCABΔilvE ΔbkdABΔaceE

MES

 ~ 220 mg/L

[10]

Integration (phaB2C2)

plasmid pYL22 (Kan^R, pBHR1)

int-P_phaC1-alsS-ilvCD

plasmid-P_CAT-kivd-yqhD

H16ΔphaCAB

MES

140 mg/L

[26]

Fatty acids

Plasmids pCT (Kan^R, pBBR1); pFP (Cm^R, RP4)

pCT-P_araBAD-acc-LTes

pFP-P_araBAD-Fas-acpS

H16ΔphaC1

Gas fermentation

60.64 mg/g CDW

[58]

Methyl ketones

Plasmid pJM20 (Kan^R, pBBR1)

P_araBAD- ‘tesA-fadB-Mlut_11700-fadM

Re2303ΔphaCAB

Gas fermentation

50 ~ 180 mg/L

[161]

Alka(e)ne

Plasmid pLC10 (Kan^R, pBBR1)

P_araBAD-ado-aar

H16ΔphaCAB

Gas fermentation

4.4 mg/L

[189]

α-Humulene

Plasmid pKR-hum (Tc^R, RSF1010, par)

P_rhaBAD-zssI-erg20-hmgS-fni-hmgR-mvaK-mvaD-mvaK2

H16PHB⁻4

MES

17 mg/g CDW

[19]

2-Hydroxy isobutyric acid

Plasmid pHCM (Kan^R, pBBR1)

P_lac-meaB-hcmA-hcmB

H16PHB⁻4

Gas fermentation

3.2 g/L

[190]

Trehalose

Plasmid pSEVA228 (Kan^R, RP4)

P_xyls-setA

H16

Gas fermentation

0.47 g/L

[191]

Sucrose

Plasmid pBADT (Kan^R, pBBR1)

P_araBAD-SPS-SPP-scrY

H16

Gas fermentation

180 mg/L

[192]

Lipochitooligosaccharides

Plasmid pBADT (Kan^R, pBBR1)

P_araBAD-nodABC

H16

Gas fermentation

1.4 mg/L

[192]

Lycopene

Plasmid (Kan^R, pBBR1)

P_lac-CrtEBI2

C5

MES

1.73 mg/L

[175]