Table 2 Possible causative alleles related to low-pH-resistance phenotype at chromosome XIII with uncommon non-synonymous coding mutations

GAS1

Beta-1,3-glucanosyltransferase; required for cell wall assembly and also has a role in transcriptional silencing; genetic interactions with histone H3 lysine acetyltransferases GCN5 and SAS3 indicate previously unsuspected functions for Gas1 in DNA damage response and cell cycle regulation

A631G

ELP6

Elp6p is part of the six-subunit elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II holoenzyme responsible for transcriptional elongation

C685A

GLC8

Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; protein abundance increases in response to DNA replication stress

C605G

FET4

Although originally identified as a low-affinity iron(II) permease, Fet4p has since been shown to import several other transition metal ions, including copper and zinc

C950T; T1656C