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Table 2 Possible causative alleles related to low-pH-resistance phenotype at chromosome XIII with uncommon non-synonymous coding mutations

From: QTL mapping of a Brazilian bioethanol strain links the cell wall protein-encoding gene GAS1 to low pH tolerance in S. cerevisiae

Gene Functiona Mutations in ACY503b
GAS1 Beta-1,3-glucanosyltransferase; required for cell wall assembly and also has a role in transcriptional silencing; genetic interactions with histone H3 lysine acetyltransferases GCN5 and SAS3 indicate previously unsuspected functions for Gas1 in DNA damage response and cell cycle regulation A631G
ELP6 Elp6p is part of the six-subunit elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II holoenzyme responsible for transcriptional elongation C685A
GLC8 Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; protein abundance increases in response to DNA replication stress C605G
FET4 Although originally identified as a low-affinity iron(II) permease, Fet4p has since been shown to import several other transition metal ions, including copper and zinc C950T; T1656C
  1. aAvailable at https://www.yeastgenome.org/
  2. bNon-synonymous uncommon mutations