Fig. 4

The model for PoCreA-CYC8–TUP1 during repression of cellulolytic gene. In glucose condition, PoCreA mainly localizes in the nucleus, binds to the promoter of the target genes, and recruits the corepressor complex PoTup1–Cyc8. Histone methyltransferase Set2 which methylates H3K36, is also involved in the regulatory network via its interaction with Cyc8. As the repression marker of cellulolytic gene expression, H3K36 methylation together with histone deacetylase Rpd3 cooperate to reestablish chromatin, thereby suppresses inappropriate transcription initiation. In addition, the corepressor PoTup1–Cyc8 also interacts with the main subunit of the RNA Pol II and thus prevents Pol II from initiating transcription