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Table 2 Number of small mutations (SNPs + INDELs) found in the evolved strains compared to the parent and mapped to either the whole reference S288c genome, the plasmid sequences that were introduced to engineer the parent strain to consume xylose, or the non-S288 genes which are present in Ethanol Red, respectively

From: Rational and evolutionary engineering of Saccharomyces cerevisiae for production of dicarboxylic acids from lignocellulosic biomass and exploring genetic mechanisms of the yeast tolerance to the biomass hydrolysate

  Total In Reference S. cerevisiae Genomea In inserted plasmidsb Ethanol Red-specific genesc
   All AA-changes Genes with AA-changes All AA-changes Genes with AA-changes All AA-changes Genes with AA-changes
All mutations 2255 2188 663 380 26 2 2 40 20 8
 In YE + SSL 1342 1290 405 246 23 2 2 28 14 5
 In MM + SSL 1947 1899 554 307 26 1 1 22 9 4
 Shared 1034 1001 297 170 23 1 1 10 3 1
New variants 188 177 101 85 8 2 2 2 0 0
 In YE + SSL 98 90 57 48 7 2 2 0 0 0
 In MM + SSL 116 106 56 49 8 1 1 2 0 0
 Shared 26 19 12 11 7 1 1 0 0 0
LOH events 2067 2011 562 295 18 0 0 38 20 8
 In YE + SSL 1244 1200 348 198 16 0 0 28 14 5
 In MM + SSL 1831 1793 498 258 18 0 0 20 9 4
 Shared 1008 982 285 159 16 0 0 10 3 1
  1. AA amino acid
  2. aS288c genome (R64, version GCF_000146045.2)
  3. bIntegrated xylose pathway
  4. cORFs that are not present in S288c
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Biotechnology for Biofuels and Bioproducts

ISSN: 2731-3654

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