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Table 3 Reported target TFs in improving S. cerevisiae resistance to stress factors

From: Response mechanisms of Saccharomyces cerevisiae to the stress factors present in lignocellulose hydrolysate and strategies for constructing robust strains

Target TF

Function

Regulation

Stress factor

Refs.

Ace2p

Activate transcription of genes encoding chitinases and glucanases

Overexpression

Acetic acid and furfural

[43]

Haa1p

Weak acid-responsive transcriptional activator

Overexpression

Organic acids

[130,131,132]

Hap4p

Transcriptional activator and global regulator of respiratory gene expression

Overexpression

Acetic acid, formic acid, and furfural

[27]

Msn2/4p

Stress-responsive transcriptional activator

Overexpression

Acetic acid, furfural, oxidative stress, and osmotic shock

[133,134,135]

Ppr1p

Zinc finger transcription factor

Overexpression

Acetic acid and ROS

[106]

Sfp1p

Regulates transcription of ribosomal protein and biogenesis genes

Overexpression

Acetic acid and furfural

[43]

Skn7p

Nuclear response regulator and transcription factor

Overexpression

Osmotic and oxidative

[136,137,138]

Tye7p

contribute to glycolytic genes activation

Overexpression

Acetic acid and furfural

[27]

Yap1p

Basic leucine zipper (bZIP) transcription factor

Overexpression

Oxidative stress, furfural, HMF, and vanillin

[67, 139, 140]

Yrr1p

Zn2-Cys6 zinc-finger transcription factor

Deletion

Vanillin

[40]