Model-based driving mechanism analysis for butyric acid production in Clostridium tyrobutyricum

Table 2 Comparison of carbon and nitrogen utilization between in vivo and in silico data^a

Substrates	In vivo	In silico growth in draft model	In silico growth in final model	Reference
Carbon sources
Fructose	+	+	+	[50]
Glucose	+	+	+	[51]
Mannitol	+	+	+	[52]
Mannose	+	+	+	[53]
Galactose	−	-	-	[54]
Xylose	+	+	+	[55]
Arabinose	+	-	+	[56]
Glycerol	+	-	+	[57]
Sucrose	−	-	−	[58]
Maltose	−	−	−	[59]
Lactose	−	−	−	In this study
Nitrogen sources
Ammonium	+	+	+	[60]
Urea	+	−	+	[61]

^aTotal 11 carbon sources and 2 nitrogen sources were selected from an experiment for validating the model. Glucose was used as the sole carbon source in simulating growth with nitrogen sources. + indicates available, −indicates unavailable

ISSN: 2731-3654