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Table 5 Parameters of l-ornithine producing strain by genetic modification

From: Improvement in l-ornithine production from mannitol via transcriptome-guided genetic engineering in Corynebacterium glutamicum

Strains

l-Ornithine titer (g/L)

Yield (g/g)

Carbon source

Cultivation

Strategies

References

C. glutamicum MTL13

54.56

0.47

Mannitol

Fed-batch

Deletion of mtlR; overexpression of mtlD and pfkB

[21]

C. glutamicum KBJ11

88.26

0.414

Glucose

Fed-batch

Deletion of argF, argR, and ncgl2228; co-overexpression of CsgapC and BsrocG

[14]

C. glutamicum XAB03

41.5

ND

Xylose and glucose

Shake flask

Heterologous expression of xylAB (X. campestris) Overexpression of pepc and araE

[40]

C. glutamicum SO26

43.6

0.34

Glucose

Fed-batch

Deletion of argF, ncgl1221, argR, putP, mscCG2, and iolR; attenuation of odhA, proB, ncgl2228, pta, cat, and pgi; overexpression of lysE, gdh, cg3035, pfkA, tkt, argCJBD, glt, and gdh2

[13]

C. glutamicum SO29

18.6

0.40

Xylose

Shake flask

Heterologous expression of xylAB operon (X. campestris)

[13]

C. crenatum Cc-QF-4

12.6 ± 0.65; 40.4

0.126 ± 0.011; ND

Glucose

Shake flask; bioreactor

Deletion of proB and argF; co-expression of exogenous Ec argA and Sm argE

[6]

C. glutamicum 1006∆argR-argJ

31.6

0.396

Glucose

Shake flask

Deletion of argR; overexpression of argJ

[41]

C. glutamicum YW06 (pSY223)

51.5

0.240

Glucose

Fed-batch

Deletion of proB, argR, and argF; overexpression of argCJBD, pgi, zwf, and tkt;

[10]

S. cerevisiae M1dM2qM3e

5.1

ND

Glucose

Fed-batch

Modular pathway rewiring

[42]

C. glutamicum ∆APE6937R42(pEC-SacC)

22.0; 27.0

ND

Sucrose; molasses

Batch

Overexpression of sacC (M. succiniciproducens)

[16]

C. glutamicum SJC8260

12.48

ND

Glucose

Shake flask

Overexpression of ncgl0462 and mutant argCJBD

[43]

C. glutamicum APE6937R42

24.1

0.298

Glucose

Bioreactor

Deletion of argF, argR, and proB; adaptive evolution in presence of l-ornithine

[4]

C. glutamicum SJC8399

13.16

ND

Glucose

Shake flask

Inactivation of gntK

[44]