Fig. 1From: Bioconversion of vitamin D3 to bioactive calcifediol and calcitriol as high-value compoundsVD3 bioconversion process. VD3 is sequentially converted to calcifediol and calcitriol by CYPs. Some uncommon CYPs can also catalyze the conversion of VD3 to calcitrol with 1α(OH)VD3 as the intermediate. Many CYPs, such as CYP27B1, can catalyze hydroxylation at two sites, as they have relatively wide substrate specificity and regioselectivityBack to article page