Fig. 1
From: Metabolic engineering of Corynebacterium glutamicum for acetate-based itaconic acid production
Central metabolism of C. glutamicum including pathways relevant for this study. Heterologously expressed CAD is marked in green. Dashed lines indicate unknown or indirect interactions. Abbreviations: ACN aconitase; AK acetate kinase; AmtR global repressor in the nitrogen regulation system; CAD cis-aconitate decarboxylase; CoA coenzyme A; CS citrate synthase; GDH glutamate dehydrogenase; GlnE adenylyltransferase; GOGAT glutamine oxoglutarate aminotransferase; GS glutamine synthetase; ICL isocitrate lyase; IDH isocitrate dehydrogenase; MctC monocarboxylic acid transporter; MQ menaquinone; MS malate synthase; PEP phosphoenolpyruvate; PEPCk PEP-carboxykinase; PTA phosphotransacetylase; PPP pentose phosphate pathway; RamA regulator of acetate metabolism A; RamB regulator of acetate metabolism B