Fig. 4
The transcriptional response to B. methylotrophicum to lysine addition. A Volcano map of differential genes in cells cultivated with and without extra lysine addition. Significantly differentially expressed genes are represented by red dots (up-regulated) and blue dots (down-regulated). The abscissa represents the fold change of gene expression in different samples, log2(Fold Change) > 1; the ordinate represents the statistical significance of the difference in gene expression, padjust < 0.05. B Pathway enrichment analysis of the significantly up-regulated genes with the corrected p-value < 0.05. C The transcriptional response of genes in NikABCDE tansporter system to lysine addition in B. methylotrophicum. D The transcriptional response of genes in FhuBCD transporter system to lysine addition in B. methylotrophicum