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Table 3 Proteins downregulated twofold or more by 15 mM furfural ( P ≤0.05)

From: A comparative multidimensional LC-MS proteomic analysis reveals mechanisms for furan aldehyde detoxification in Thermoanaerobacter pseudethanolicus 39E

Locus

Fold change

Description

P-value

Amino acid metabolism

  

Teth39_0216

-3.10

Glutamate synthase, homotetrameric

0.000

Teth39_0217

-2.47

Oxidoreductase FAD/NAD(P)-binding domain

0.004

Teth39_0487

-2.15

Alanine racemase

0.038

Teth39_1661

-3.77

Glutamine amidotransferase, class II

0.016

Teth39_2007

-2.58

Aromatic amino acid beta-eliminating lyase

0.004

Cell division/sporulation/motility

 

Teth39_0175

-52.70

Peptidoglycan-binding LysM

0.000

Teth39_0252

-30.04

YabP family protein

0.000

Teth39_1446

-2.42

Cell division topological specificity factor MinE

0.016

Teth39_1772

-2.33

Flagellar protein FlaG protein

0.011

Teth39_1783

-2.51

Flagellar hook-associated protein 3

0.009

Energy related

  

Teth39_0466

-2.27

Thiamine pyrophosphate enzyme domain

0.038

Hydrogenase related

  

Teth39_0221

-2.17

Hydrogenase with PAS/PAC sensor

0.005

Teth39_1458

-2.05

Hypothetical protein

0.005

Teth39_1459

-24.50

Histidine kinase

0.000

Hypothetical proteins

  

Teth39_0794

-5.93

Hypothetical protein

0.041

Teth39_0842

-36.68

Hypothetical protein

0.000

Nucleotide related

  

Teth39_1357

-2.51

Metal-dependent phosphohydrolase

0.002

Teth39_2157

-9.29

SirA family protein

0.000

Redox proteins

  

Teth39_0445

-2.19

Thioredoxin reductase

0.002

Teth39_1916

-2.73

Oxidoreductase FAD/NAD(P)-binding domain

0.001

Teth39_1917

-4.88

4Fe-4S ferredoxin, iron-sulfur binding domain

0.000

Teth39_2155

-4.30

FAD-dependent pyridine nucleotide-disulfide oxidoreductase

0.000

Transcriptional regulator

 

Teth39_0150

-2.56

Transcriptional regulator, DeoR family

0.011

Teth39_0757

-3.07

Putative cold-shock DNA-binding domain protein

0.029

Teth39_1109

-2.27

Sporulation transcriptional activator Spo0A

0.006

Teth39_1292

-2.06

Hypothetical protein

0.019

Teth39_1796

-2.17

Two-component transcriptional regulator, winged helix family

0.015

Transporters

   

Teth39_0333

-2.98

PTS system, fructose subfamily, IIC subunit

0.001

Teth39_0334

-2.90

PTS system, fructose-specific, IIB subunit

0.019

Vitamin related

  

Teth39_0787

-4.71

Lipoic acid synthetase

0.033

Other

   

Teth39_0542

-2.43

Dihydroxyacetone kinase, DhaK subunit

0.006

Teth39_1065

-2.21

HAD superfamily (subfamily IIIA) phosphatase, TIGR01668

0.024

Teth39_1216

-2.04

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase

0.011

  1. Sorted by general cellular function. Proteins in boldface are regulated greater than fivefold. Descriptions are from the National Center for Biotechnology Information.