Stage | Time | Trend | Dynamics | Waves, modules, transcripts | Functional highlights (corrected p value) |
---|---|---|---|---|---|
Early | 0–18 min | Up | Monotonic | 2, 7, 105 | Ammonium transport (1.7e−9) Potassium ion transmembrane transport (1.4e−5) Ion channel activity (2.8e−3) Ion transport (3.4e−3) Protein kinase activity (1.3e−2) |
Transient | 2, 7, 118 | ||||
Down | Monotonic | 1, 1, 17 | Ribosome biogenesis (6.3e−8) Transcription (3.7e−6) rRNA processing (2.9e−5) Pseudouridine synthesis (7.0e−5) Methyltransferase activity (9.0e−5) | ||
Transient | 1, 17, 202 | ||||
Mid | 18–60 min | Up | Monotonic | 4, 24, 304 | Mitochondrial pyruvate transport (1.0e−6) Glutamine biosynthetic process (3.0e−5) Lipid metabolic process (5.2e−5) Amine metabolic process (7.5e−5) Proteolysis (9.6e−3) |
Transient | 3, 7, 110 | ||||
Down | Monotonic | 4, 44, 552 | Purine nucleotide biosynthetic process (5.1e−5) Fatty acid beta-oxidation (4.9e−4) Pseudouridine synthesis (8.7e−4) Malate dehydrogenase activity (1.6e−3) Fatty acid biosynthetic process (1.9e−3) | ||
Transient | 4, 15, 237 | ||||
Late | 1–8 h | Up | Monotonic | 3, 12, 177 | DNA replication (8.6e−7) Microtubule cytoskeleton organization (1.1e−4) NADP binding (3.5e−3) Lipid metabolic process (1.8e−2) Nucleotide binding (2.4e−2) |
Transient | 2, 8, 139 | ||||
Down | Monotonic | 3, 47, 489 | Photosynthesis (7.7e−31) Protein folding (1.0e−13) Fructose-bisphosphate aldolase activity (8.4e−6) Cell redox homeostasis (4.9e−5) Fatty acid biosynthetic process (7.5e−3) | ||
Transient | 2, 5, 95 |