Table 1 Overview of metabolic engineering studies on the production of l-methionine by C. glutamicum and E. coli

E. coli W3110

ΔthrBCΔmetJ metK^*/pMW118-P_thr-metA^*

Yes

0.24

(Shake flask)

Usuda and Kurahashi 2005 [5]

C. glutamicum ATCC13032

ΔthrBΔmcbR/pJYW-4-hom^fbr-lysC^fbr-brnFE

Yes

6.3

(3 L fed-batch,)

Qin, et al. 2015 [6]

C. glutamicun

ATCC13032

ΔmetDΔthrB dapA^A1G lysC^fbr pyc^fbr zwf^fbr gnd^fbr

Yes

6.85

(Shake flask)

Li, et al. 2016 [8]

E. coli W3110

ΔthrBCΔmetJΔlysA/ pTrc99A-metA^*-yjeH

Yes

9.75

(5 L fed-batch)

Huang, et al. 2017 [7]

C. glutamicun ATCC13032

zwf^fbr gnd^fbr/pLY-4-gapC

No

0.64

(N)

Liu, et al. 2022 [9]

E. coli W3110

ΔthrBCΔmetJΔlysA Trc-metH Trc-metF Trc-cysE Trc-serB Trc-serC/pTrc99A-metA^*-yjeH- serA^fbr-gltA

Yes

17.74

(5 L fed-batch)

Niu, et al. 2023 [10]