Fig. 8From: Regulation of acetate tolerance by small ORF-encoded polypeptides modulating efflux pump specificity in Methylomonas sp. DH-1Model for SEP-dependent regulation of the WatABO pump upon acetate stress. Under normal conditions, the WatABO pump extrude a wide range of weak organic acids including acetate, formate, lactate, and propionate. Upon acetate stress, activated WatR induces transcription of WatABO pump and watS smORF genes. WatS SEP binds to the WatABO pump, increasing the specificity toward acetate for efficient removal of acetate from cellsBack to article page