Figure 4

Phylogenetic analysis of the AA10 LPMO superfamily. MrBayes phylogenetic tree for the 374 AA10 protein sequences. The tree was generated using the catalytic domain of the AA10 protein only. Additional carbohydrate-binding domains that are present in the full protein sequence are indicated in the CBM column, but were not included in the calculation of the tree structure. Solved structures have been mapped onto the tree and colors represent conservation of residues across the whole AA9 family, and in the three modeled structures for Streptomyces sp. SirexAA-E and AA10 enzymes. Gene expression data for the six AA10 isoforms from SirexAA-E showing fold change in transcripts from glucose grown cells to either cellulose or chitin grown cells.