Analysis of Clostridium beijerinckii NCIMB 8052’s transcriptional response to ferulic acid and its application to enhance the strain tolerance

Table 1 GO terms showing significant changes in C. beijerinckii cultures exposed to 0.5 g/L ferulic acid

Exposure ^a	Category ^b	GO ID	GO term	P value	Benjamini ^c	Count ^d
Up-regulated
I	NS^e
S	MF	GO:0048037	Cofactor binding	5.14 E⁻⁰⁵	0.0102	47
	MF	GO:0016163	Nitrogenase activity	4.47 E⁻⁰⁴	0.0438	8
L	BP	GO:0006265	DNA topological change	4.12 E⁻⁰⁶	0.0014	11
Down-regulated
I	MF	GO:0016887	ATPase activity	3.85 E⁻⁰⁵	0.0124	38
S	CC	GO:0019861	Flagellum	1.14 E⁻⁰⁸	4.20 E⁻⁰⁷	19
	MF	GO:0017076	Purine nucleotide binding	2.41 E⁻⁰⁴	0.0129	95
	BP	GO:0006935	Chemotaxis	0.0014	0.0316	22
	BP	GO:0006812	Cation transport	4.09 E⁻⁰⁴	0.0150	20
	BP	GO:0016310	Phosphorylation	0.0011	0.0266	28
	BP	GO:0009309	Amine biosynthetic process	0.0023	0.0444	25
L	NS^e

^aExposure time to ferulic acid: I, initial; S, short-term; L, long-term; ^bcategories - MF, molecular function; BP, biological process; CC, cellular component; ^csignificant groups were selected based upon Benjamini (<0.05); ^dthe count is the number of genes within the given GO term showing a significant change in expression. The number in parenthesis is the percentage of all genes showing a significant change in their expression levels. ^eNo significant group identified.

ISSN: 2731-3654