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Table 2 KEGG pathways showing significant changes in C. beijerinckii cultures exposed to 0.5 g/L ferulic acid

From: Analysis of Clostridium beijerinckii NCIMB 8052’s transcriptional response to ferulic acid and its application to enhance the strain tolerance

Exposure a

KEGG ID

Pathway definition

P value

Benjamini b

Count c

Up-regulated

    

I

cbe00330

Arginine and proline metabolism

0.0010

0.0329

11

S

cbe02010

ABC transporters

1.44 E−07

9.47 E−06

51

 

cbe00450

Selenoamino acid metabolism

1.37 E−05

4.52 E−04

11

 

cbe00230

Purine metabolism

1.55 E−04

0.0026

23

 

cbe00910

Nitrogen metabolism

1.34 E−04

0.0030

15

 

cbe00920

Sulfur metabolism

2.32 E−04

0.0031

9

 

cbe00330

Arginine and proline metabolism

0.0032

0.0347

13

L

cbe02010

ABC transporters

1.07 E−05

6.09 E−04

33

 

cbe00330

Arginine and proline metabolism

6.08 E−04

0.0172

11

Down-regulated

    

I

NSd

    

S

cbe00400

Phenylalanine, tyrosine and tryptophan biosynthesis

1.94 E−11

1.01 E−09

17

 

cbe02040

Flagellar assembly

2.81 E−10

7.30 E−09

19

L

NS

    
  1. aExposure time to ferulic acid: I, initial; S, short-term; L, long-term; bsignificant groups were selected based upon Benjamini (<0.05); cumber of genes within the given KEGG ID showing a significant change in their expression level; dno significant group identified.