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Table 4 Recently reported literature values for lipid titer, yield, and productivity with engineered Yarrowia lipolytica strains

From: Engineering of a high lipid producing Yarrowia lipolytica strain

Parental strain Strain Lipid pathway genetic engineering Process Sugar consumed (g/L) Lipid titer (g/L) Overall yield (g/g) Overall volumetric productivity (g/L/h) Cell specific productivity (g/g/h) Reference
po1g MTYL037 control strain (ura + lacZ) Batch 80 2.5 0.03 0.02 0.002 [19]
po1g MTYL065 DGA1 ACC1 Batch 80 17.6 0.20 0.14 0.017 [19]
po1g YL-ad9 DGA1 ACC1 SGD1 Fed-batch 235 55 0.23 0.71 0.038 [22]
po1f po1f leu + ura + control strain Batch 80 3 0.04 0.02 0.001 [21]
po1f pex10 mfe1 leu + ura + DGA1 DGA1 Δpex10 Δmfe1 Batch 80 16.1 0.20 0.11 0.017 [21]
po1f pex10 mfe1 leu + ura + DGA1 DGA1 Δpex10 Δmfe1 Batch 160 25.3 0.16 0.21 [21]
po1f L36 DGA1 leu + ura + DGA1 mga2-G643R Fed-batch 160 25 0.21 0.13 0.018 [24]
po1f E26E1 DGA1 Δpex10 Δmfe1 uga-P209S Batch 160 39.1 0.24 0.56 0.035 [23]
po1d JMY2593 control strain (SUC2) Batch 60 2.6 0.04 0.04 0.004 [26]
po1d JMY3582 DGA2(x3) Δdga1 Δdga2 Δlro1 Δare1 Batch 60 6.5 0.11 0.09 0.010 [26]
NS18 NS18 wild-type Batch 60 3.6 0.06 0.04 0.002 this study
NS18 NS432 DGA1 DGA2 Δtgl3 Batch 140 30.8 0.21 0.27 0.048 this study
NS18 NS432 DGA1 DGA2 Δtgl3 Fed-batch 430 84.5 0.20 0.73 0.044 this study
  1. Where necessary, values for overall and cell specific productivities were estimated from figures of cited references [24, 26]