Engineering of a high lipid producing Yarrowia lipolytica strain

Table 4 Recently reported literature values for lipid titer, yield, and productivity with engineered Yarrowia lipolytica strains

Parental strain	Strain	Lipid pathway genetic engineering	Process	Sugar consumed (g/L)	Lipid titer (g/L)	Overall yield (g/g)	Overall volumetric productivity (g/L/h)	Cell specific productivity (g/g/h)	Reference
po1g	MTYL037	control strain (ura + lacZ)	Batch	80	2.5	0.03	0.02	0.002	[19]
po1g	MTYL065	DGA1 ACC1	Batch	80	17.6	0.20	0.14	0.017	[19]
po1g	YL-ad9	DGA1 ACC1 SGD1	Fed-batch	235	55	0.23	0.71	0.038	[22]
po1f	po1f leu + ura +	control strain	Batch	80	3	0.04	0.02	0.001	[21]
po1f	pex10 mfe1 leu + ura + DGA1	DGA1 Δpex10 Δmfe1	Batch	80	16.1	0.20	0.11	0.017	[21]
po1f	pex10 mfe1 leu + ura + DGA1	DGA1 Δpex10 Δmfe1	Batch	160	25.3	0.16	0.21	–	[21]
po1f	L36 DGA1 leu + ura +	DGA1 mga2-G643R	Fed-batch	160	25	0.21	0.13	0.018	[24]
po1f	E26E1	DGA1 Δpex10 Δmfe1 uga-P209S	Batch	160	39.1	0.24	0.56	0.035	[23]
po1d	JMY2593	control strain (SUC2)	Batch	60	2.6	0.04	0.04	0.004	[26]
po1d	JMY3582	DGA2(x3) Δdga1 Δdga2 Δlro1 Δare1	Batch	60	6.5	0.11	0.09	0.010	[26]
NS18	NS18	wild-type	Batch	60	3.6	0.06	0.04	0.002	this study
NS18	NS432	DGA1 DGA2 Δtgl3	Batch	140	30.8	0.21	0.27	0.048	this study
NS18	NS432	DGA1 DGA2 Δtgl3	Fed-batch	430	84.5	0.20	0.73	0.044	this study

Where necessary, values for overall and cell specific productivities were estimated from figures of cited references [24, 26]

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