Fig. 3

Genome-wide transcriptome analysis for WT and ΔhepA. WT and ΔhepA were cultivated in cellulose and wheat bran medium, which are optimum media for cellulolytic enzyme formation. mRNA from WT and ΔhepA at cultivation time of 48 h was collected and subjected to high-throughput Illumina sequencing. a Function enrichment analysis of upregulated or downregulated (≥twofold, FDR < 0.001) gene sets in ΔhepA compared with WT by Blast2GO with the threshold at FDR ≤ 0.05. Red bars function enrichment analysis of upregulated gene sets; green bars function enrichment analysis of downregulated gene sets. b Expression levels of the top 10 extracellular glycoside hydrolase genes. The copy number of unambiguous transcripts for each gene was normalized to RPKM (reads per kilobases per million reads)