Fig. 4

Closed catalysis cycle and the inhibiting mechanism by guaiacol in LiPH8-catalyzed degradation of VE dimer. Under catalysis of LiPH8/H₂O₂, VAD and guaiacol were detected as released products from degradation of VE dimer. The paths depicted in red lead to the formation of inactive compound III when suicide coupling between W251 and guaiacol occurs. In the closed catalytic cycle, the stoichiometric ratio is described as 1:2:2 for [H₂O₂]:[VAD]:[Guaiacol]