Fig. 1

Simplified overview of acetyl-CoA metabolism and associated naringenin synthesis pathway in S. cerevisiae. Acetyl-CoA is generated in different compartments in yeast, including mitochondria (blue), cytosol [25], and peroxisome (not shown). Three genes (4CL, CHS, and CHI) for naringenin synthesis were introduced into yeast genome. In addition, the rate-limiting enzyme of CoA synthesis, pantothenate kinase (PanK), and PDH bypass (ALD6 and SeAcs ^L641P) were introduced into S. cerevisiae to improve its acetyl-CoA level in cytosol