Fig. 5
From: A new genome-scale metabolic model of Corynebacterium glutamicum and its application
Metabolic interventions predicted using OptForceMUST for l-proline overproduction in wild-type C. glutamicum ATCC13032 (a) predicted by iCW773 (left) and ModelCg 2 (right) and in the mutant strain C. glutamicum ATCC13032 ΔputA (b) predicted by iCW773 (left) and ModelCg 2 (right). Genes encoding relevant enzymes are depicted in italics next to the arrows: fda: fructose-bisphosphate aldolase; gltA: citrate synthase; kgd: α-oxoglutarate dehydrogenase; pfkA: phosphofructokinase; proA: glutamate-5-semialdehyde dehydrogenase; proB: γ-glutamyl kinase; proC: pyrroline-5-carboxylate reductase; putA: proline dehydrogenase and Δ1-pyrroline-5-carboxylate dehydrogenase. For other genes, see Figs. 3 and 4. 1pyr5c: Δ1-pyrroline-5-carboxylate; glu5p: glutamate-5-phosphate; glu5sa: glutamate-5-semialdehyde; l-ala: l-alanine; l-glu: l-glutamate; l-pro: l-proline. For other abbreviations, see Figs. 3 and 4