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Fig. 2 | Biotechnology for Biofuels

Fig. 2

From: An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in Saccharomyces cerevisiae

Fig. 2

Metabolic pathway for 1-octanol production in S. cerevisiae from glucose via fatty acid biosynthesis. A mutant version of S. cerevisiae FAS (Fas1R1834K/Fas2) produces octanoyl-CoA which is hydrolyzed by endogenous thioesterases (TE) to the free octanoic acid [53]. A heterologous carboxylic acid reductase (CAR) from M. marinum then converts the free fatty acid to octanal which is further reduced to 1-octanol by endogenous alcohol dehydrogenases (ADH) and aldehyde reductases (ALR) [29]. CAR must be activated by the phosphopantetheinyl tranferase Sfp from Bacillus subtilis [31]. Heterologous or mutated enzymes are marked in blue. FASRK means FASR1834K

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