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Table 1 Biomarker metabolites identified in each inhibitor-treated group

From: Proteomic and metabolomic analysis of the cellular biomarkers related to inhibitors tolerance in Zymomonas mobilis ZM4

Metabolites VIP values
FA AA F H P C
Glucose 5.41# 5.70# \ \ \ \
Oxoproline 5.31 3.50 5.10 4.57 2.40# 2.42#
Glycerol 4.66 4.13 3.21 \ 2.20# 1.78#
Alanine 3.88 \ \ \ \ 3.91#
Gluconic lactone 2.77# \ 1.81 \ 4.30 3.25#
d-Glyceric acid 2.52 2.30 1.64 1.60 2.34 \
Leucine 2.29 \ 1.92# \ \ 3.11#
3-Hydroxypropionic acid 1.94 1.76 \ \ \ \
Lysine 1.67 \ 1.01 \ \ \
2-hydroxypyridine 1.59 1.19 1.29 \ 1.02 \
Phenylalanine 1.53 1.20 1.09 1.26 \ \
Inosine 1.37 1.61 1.85# \ \ \
Trehalose 1.37 \ 1.50# \ 1.02# 2.32#
Lactic acid 1.15 \   \ 1.19 \
Ribose 1.13 1.32 1.21 1.16 \ \
Gluconic acid 1.11# 4.95# 3.86# 6.86# 6.01 6.70#
Tyrosine 1.05 \ \ \ \ \
l-Allothreonine 1.03 1.30# 1.57 \ \ 3.25#
O-Phosphoserine 1.02# \ \ \ \ \
Phosphate \ 2.58 3.36 2.81 \ \
Isoleucine \ 2.10# 1.99# 2.31# 2.34# 2.36#
Linoleic acid methyl ester \ 2.04# 3.21# 2.22# 2.14 1.33#
Glycine \ 1.69# 1.65# 1.75# 1.93# 1.87#
Stearic acid \ 1.53# 1.89# \ \ 1.33#
Valine \ 1.52# 4.10# 2.35# 2.35# 2.19#
Proline \ 1.49# 1.58# 1.50# 1.95# 1.15#
Oleic acid \ 1.43# 1.10# \ \ 1.29#
Serine \ 1.43# 1.04# 1.15# 2.30# 2.10#
Succinic acid \ 1.17# 1.84# 1.43# 1.25# 1.32#
Tyrosine \ 1.02 \ \ \ \
Dihydroxyacetone \ \ 1.52# 2.69# 5.72# 1.35#
Aspartic acid \ \ 1.29 1.16 1.50 \
Palmitic acid \ \ 1.00 \ \ \
1,2-Cyclohexanedione \ \ \ 4.56# \ 2.11#
  1. VIP variable importance to projection, obtained by OPLS-DA analysis. FA cells treated by formic acid, AA cells treated by acetic acid, F cells treated by furfural, H cells treated by 5-HMF, P cells treated by phenol, C cells treated by combined inhibitors. Symbol “\” denotes the metabolite is not identified as a biomarker in the relevant group. Superscript symbol “#” denotes the metabolite is up-regulated. Metabolite without symbol denotes it is down-regulated