Table 1 Biomarker metabolites identified in each inhibitor-treated group

Glucose

5.41^#

5.70^#

\

\

\

\

Oxoproline

5.31

3.50

5.10

4.57

2.40^#

2.42^#

Glycerol

4.66

4.13

3.21

\

2.20^#

1.78^#

Alanine

3.88

\

\

\

\

3.91^#

Gluconic lactone

2.77^#

\

1.81

\

4.30

3.25^#

d-Glyceric acid

2.52

2.30

1.64

1.60

2.34

\

Leucine

2.29

\

1.92^#

\

\

3.11^#

3-Hydroxypropionic acid

1.94

1.76

\

\

\

\

Lysine

1.67

\

1.01

\

\

\

2-hydroxypyridine

1.59

1.19

1.29

\

1.02

\

Phenylalanine

1.53

1.20

1.09

1.26

\

\

Inosine

1.37

1.61

1.85^#

\

\

\

Trehalose

1.37

\

1.50^#

\

1.02^#

2.32^#

Lactic acid

1.15

\

\

1.19

\

Ribose

1.13

1.32

1.21

1.16

\

\

Gluconic acid

1.11^#

4.95^#

3.86^#

6.86^#

6.01

6.70^#

Tyrosine

1.05

\

\

\

\

\

l-Allothreonine

1.03

1.30^#

1.57

\

\

3.25^#

O-Phosphoserine

1.02^#

\

\

\

\

\

Phosphate

\

2.58

3.36

2.81

\

\

Isoleucine

\

2.10^#

1.99^#

2.31^#

2.34^#

2.36^#

Linoleic acid methyl ester

\

2.04^#

3.21^#

2.22^#

2.14

1.33^#

Glycine

\

1.69^#

1.65^#

1.75^#

1.93^#

1.87^#

Stearic acid

\

1.53^#

1.89^#

\

\

1.33^#

Valine

\

1.52^#

4.10^#

2.35^#

2.35^#

2.19^#

Proline

\

1.49^#

1.58^#

1.50^#

1.95^#

1.15^#

Oleic acid

\

1.43^#

1.10^#

\

\

1.29^#

Serine

\

1.43^#

1.04^#

1.15^#

2.30^#

2.10^#

Succinic acid

\

1.17^#

1.84^#

1.43^#

1.25^#

1.32^#

Tyrosine

\

1.02

\

\

\

\

Dihydroxyacetone

\

\

1.52^#

2.69^#

5.72^#

1.35^#

Aspartic acid

\

\

1.29

1.16

1.50

\

Palmitic acid

\

\

1.00

\

\

\

1,2-Cyclohexanedione

\

\

\

4.56^#

\

2.11^#