Development of modified HCH-1 kinetic model for long-term enzymatic cellulose hydrolysis and comparison with literature models

Table 3 Comparison of long-term enzymatic hydrolysis models

Model	N (Obs)	Parameter	SSE	AICc	Methodology
Modified HCH-1 (16)	112	11	236.7	110.9	Ads
Holtzapple et al. [3] (original HCH-1)	112	4	1630.7	310.5	Ads
Drissen et al. [26]	112	11	600.8	215.2	Ads, M–M
Fan and Lee [27]	112	11	679.7	229.0	Ads
Liao et al. [28]	112	5	1313.7	288.5	Ads
Peri et al. [21]	112	12	2657.6	384.3	Ads, M–M
Fenila and Shastri [5]	112	22	2080.9	385.5	Ads, M–M
Kadam et al. [4]	112	18	2338.6	386.4	Ads, M–M
Gusakov et al. [29]	112	16	2879.2	404.0	M–M
Philippidis et al. [30]	112	7	9139.8	510.4	Ads, M–M
Modified HCH-1 (8)^a	56	11	115.2	71.3	Ads
Shen and Agblevor [31]^a	56	4	493.8	133.1	Ads
Zhang et al. [32]^a	56	3	692.6	149.6	Ads
Rosales-Calderon et al. [33]^a	56	3	692.6	149.6	Ads
Nidetzky and Steiner [18]^a	56	5	743.9	158.5	Ads

M–M Michaelis–Menten kinetics, Ads adsorption-based approach
^aOnly eight reaction conditions were fit [0 g/L initial glucose, four substrate concentrations (40, 60, 80, and 100 g/L) × two enzyme loadings (2 and 5 mg/g)]

ISSN: 2731-3654