Fig. 7

Two bioreactor process for continuous removal of aromatic inhibitors and production of any growth-associated product. Reactor 1 (left) allows for continuous growth of Acinetobacter baylyi on mixtures of aromatics such as benzoate and 4-hydroxybenzoate. A strain with a gcd knockout prevents glucose, xylose, and arabinose consumption. An industrial microbe may now grow continuously in Reactor 2 (right) on the residual sugars to generate a biochemical product. Conditions found in Reactor 2 (e.g., different temperature or pH) should prevent metabolism of the product by A. baylyi