Fig. 1
From: Engineering the oleaginous yeast Yarrowia lipolytica for production of α-farnesene
Metabolic pathway of α-farnesene synthesis from glucose in Yarrowia lipolytica. In the first module, acetyl-CoA is converted to mevalonate, providing precursor for the second module. In the second module, mevalonate is converted to α-farnesene. Red bold font, expression of heterologous proteins. Black bold font, overexpression of endogenous proteins. AtoB, acetyl-CoA acetyltransferase from Escherichia coli; HMGR, NADH-dependent HMG-CoA reductase from Bordetella petrii; α-FS, α-farnesene synthetase from apple (Malus × domestica)