Fig. 2
Time-resolved trend clustering analysis. a, b Cluster of metabolite and protein expression patterns in response to nutrient stress. c Six temporal metabolite change/protein expression modules revealed by unsupervised clustering analysis. d Top pathways of each cluster from enrichment results. e Molecular function (MF), Cellular component (CC) and Biological process (BP) of GO enrichment results of each cluster. Closely correlated metabolites or proteomics (R2 > 0.75) in each cluster were selected for pathway enrichment or GO enrichment analysis